First use of myeloid colony-stimulating factors in humans
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چکیده
منابع مشابه
Use of colony-stimulating factors in the treatment of acute myeloid leukemia.
I N THIS ISSUE OF BLOOD, Ohno et a l l become the first to report a trial in which patients with acute myeloid leukemia (AML) received granulocyte colony-stimulating factor (G-CSF) both before and during, as well as after, chemotherapy. Fifty-eight patients in relapse or resistant to 2 courses of initial therapy (n = 50) or with untreated disease arising out of a myelodysplastic syndrome (n = 8...
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The scope of functional heterogeneity in macrophages has been defined by two polarized end states known as M1 and M2, which exhibit the proinflammatory activities necessary for host defense and the tissue repair activities required for restoration of homeostasis, respectively. Macrophage populations in different tissue locations exist in distinct phenotypic states across this M1/M2 spectrum and...
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The effects of recombinant human interleukin-3 (IL-3) and recombinant human granulocyte colony-stimulating factor (G-CSF) on the growth of myeloid progenitor cells (CFU-C) in semisolid agar culture were studied in two patients with Kostmann-type congenital neutropenia. CFU-C growth in bone marrow cells from patients was significantly reduced in response to various concentrations of either IL-3 ...
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Granulocyte colony-stimulating factor is a cytokine able to stimulate both myelopoiesis and hematopoietic stem cell mobilization, which has seen it used extensively in the clinic to aid hematopoietic recovery. It acts specifically via the homodimeric granulocyte colony-stimulating factor receptor (G-CSFR), which is principally expressed on the surface of myeloid and hematopoietic progenitor cel...
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Life span of mature blood cells is ephemeral, reqUIrIng hematopoiesis throughout life. A complex network of hematopoietic progenitor cells and cytokines maintain an enormous daily production of granulocytes, monocytes, erythrocytes, platelets, and lymphocytes. This population of hematopoietic cells must be able to respond rapidly to changing needs such as bleeding, infections, cancer, or exposu...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2013
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2013.57